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This methylation profile is now acquired in the MBL stage3 and continues to be reasonably stable eventually. Nonetheless, some CLL have intratumor variability in selected regions, which can change the expression of several genes and facilitate tumor evolution.seventy one Of note, this variability is bigger in U-CLL than in M-CLL and is also connected with growing number of subclones.seven,71
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れたかを表しており，円が小さいほどその地点で判別され た回数は少なくなる．グラフから，設置したビーコンの付
translocations or amplifications in addition to the genomic alterations presently existing in the original CLL, but lack the typical mutations observed in Key DLBCL indicating which they may possibly correspond to a unique biological class.
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